In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)

被引：3

作者：

Renda, Maria Concetta ^{[1
]}

Maggio, Aurelio ^{[1
]}

机构：

[1] Osped Riuniti Villa Sofia Cervello, UOC Ematol Con Talassemia 2, Palermo, Italy

来源：

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES | 2009年 / 1卷 / 01期

关键词：

D O I：

10.4084/MJHID.2009.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In utero haematopoietic stem cell transplantation (IUHSCT) is a non-myeloablative approach for the prenatal treatment of genetic disorders. However, in target disorders, where there is not a selective advantage for donor cells, a useful donor-cell chimerism has not been achieved. There are three possible barriers to engraftment following IUHSCT: limited space in the fetus due to host-cell competition; the large number of donor cells needed, and the immunological asset of recipient.

引用

页数：6

共 46 条

[1]

Almeida-Porada G, 1998, BLOOD, V92, p116A

[2] Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero [J].

Almeida-Porada, G ;

Flake, AW ;

Glimp, HA ;

Zanjani, ED .

EXPERIMENTAL HEMATOLOGY, 1999, 27 (10) :1569-1575

[3] Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation [J].

Almeida-Porada, G ;

Porada, CD ;

Tran, N ;

Zanjani, ED .

BLOOD, 2000, 95 (11) :3620-3627

[4] The human-sheep chimeras as a model for human stem cell mobilization and evaluation of hemapoietic grafts' potential [J].

Almeida-Porada, Graca ;

Porada, Christopher ;

Gupta, Nicole ;

Torabi, Ali ;

Thain, David ;

Zanjani, Esmail D. .

EXPERIMENTAL HEMATOLOGY, 2007, 35 (10) :1594-1600

[5] ADULT BONE-MARROW-DERIVED PLURIPOTENT HEMATOPOIETIC STEM-CELLS ARE ENGRAFTABLE WHEN TRANSFERRED IN-UTERO INTO MODERATELY ANEMIC FETAL RECIPIENTS [J].

BLAZAR, BR ;

TAYLOR, PA ;

VALLERA, DA .

BLOOD, 1995, 85 (03) :833-841

[6] CD26 inhibition and hematopoiesis: a novel approach to enhance transplantation [J].

Campbell, Timothy B. ;

Broxmeyer, Hal E. .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2008, 13 :1795-1805

[7] Modulation of hematopoietic stem cell homing and engraftment by CD26 [J].

Christopherson, KW ;

Hangoc, G ;

Mantel, CR ;

Broxmeyer, HE .

SCIENCE, 2004, 305 (5686) :1000-1003

[8] TRANSPLANTATION OF FETAL CELLS [J].

CROMBLEHOLME, TM ;

LANGER, JC ;

HARRISON, MR ;

ZANJANI, ED .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1991, 164 (01) :218-230

[9] Early chimerism threshold predicts sustained engraftment and NK-cell tolerance in prenatal allogeneic chimeras [J].

Durkin, Emily T. ;

Jones, Kelly A. ;

Rajesh, Deepika ;

Shaaban, Aimen F. .

BLOOD, 2008, 112 (13) :5245-5253

[10] In utero hematopoietic stem cell transplantation: Ontogenic opportunities and biologic barriers [J].

Flake, AW ;

Zanjani, ED .

BLOOD, 1999, 94 (07) :2179-2191

← 1 2 3 4 5 →