NEW DIRECTIONS IN THE BIOLOGY AND THERAPY OF CHRONIC MYELOID-LEUKEMIA

被引:8
作者
DEISSEROTH, AB
ZHANG, W
CHA, Y
YUAN, TY
CHEN, HC
SIMS, S
WEDRYCHOWSKI, A
GAO, PQ
HUSTON, L
FILACCIO, M
CLAXTON, D
KORNBLAU, S
JOHNSON, E
HOWARD, OMZ
ANDERSSON, B
DELGIGLIO, A
GRESSOT, L
KANTARJIAN, H
TALPAZ, M
KHOURI, I
CHAMPLIN, R
ANDREEFF, M
GAOZZA, E
SEONG, D
SUH, SP
ELLERSON, D
HU, GY
CHOU, M
机构
[1] The Department of Hematology and the Department of Clinical Immunology and Biological Therapy, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
关键词
BIOLOGY; THERAPY OF CML;
D O I
10.3109/10428199209064884
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Great excitement surrounded the initial discovery of the Philadelphia chromosome translocation and the molecular rearrangement of the abl protooncogene which is generated by this translocation in chronic myelogenous leukemia (CML). In this review, we will discuss how molecular analysis of the biological abnormalities generated in the CML cells by this molecular rearrangement can be applied to new directions in therapy for this disease. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码:89 / 95
页数:7
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