ASYMMETRIC BAYLIS-HILLMAN REACTIONS USING CHIRAL 2,3-DISUBSTITUTED 1,4-DIAZABICYCLO[2.2.2]OCTANES CATALYSTS UNDER HIGH-PRESSURE CONDITIONS

被引：117

作者：

OISHI, T ^{[1
]}

OGURI, H ^{[1
]}

HIRAMA, M ^{[1
]}

机构：

[1] TOHOKU UNIV,FAC SCI,DEPT CHEM,SENDAI,MIYAGI 98077,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 06期

关键词：

D O I：

10.1016/0957-4166(95)00153-G

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral C-2-symmetric 2,3-disubstituted 1,4-diazabicyclo[2,2.2]octanes (DABCOs) (1) have been utilized as catalysts for asymmetric Baylis-Hillman reactions. Optically active alpha-methylene-beta-hydroxyalkanone was obtained in up to 47% ee. Under high pressure conditions, a remarkable enhancement of both reaction rate and enantioselectivity has been observed.

引用

页码：1241 / 1244

页数：4

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