ADJUVANT EFFECT OF LIPOSOMES AND ADAMANTYLAMIDE DIPEPTIDE ON ANTIGENICITY OF ENTRAPPED SYNTHETIC PEPTIDE DERIVED FROM HIV-1 TRANSMEMBRANE REGION GLYCOPROTEIN GP41

被引：11

作者：

TURANEK, J

TOMAN, M

NOVAK, J

KRCHNAK, V

HORAVOVA, P

机构：

[1] INST SERA & VACCINES, CR-100103 PRAGUE 10, CZECH REPUBLIC

[2] ACAD SCI CZECH REPUBL, INST ORGAN CHEM & BIOCHEM, PRAGUE 6, CZECH REPUBLIC

来源：

IMMUNOLOGY LETTERS | 1994年 / 39卷 / 02期

关键词：

GLYCOPROTEIN; 41; ADAMANTYLAMIDE DIPEPTIDE; SYNTHETIC PEPTIDE ANTIGEN; HIV-1; LIPOSOME; (MOUSE);

D O I：

10.1016/0165-2478(94)90101-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The synthetic peptide antigen (Ag) (the primary structure Tyr-Leu-Lys-Asp-Gln-Gln-Leu-Leu-Gly-Ile-Trp-Gly-Cys-Ser-Gly-Lys-Leu-Ile- Cys-Thr derived from the envelope glycoprotein gp41 of the human immunodeficiency virus type 1 (HIV-1) and exerting specificity with all HIV-1-positive sera available in the Czech Republic (and also in a panel of 10,000 sera from WHO)) was conjugated with bovine serum albumin (BSA) and encapsulated into liposomes. Adjuvant activities of liposomes with various lipid compositions were compared with Freund's complete adjuvant (FCA) and with aluminium hydroxide (AL). The immune response to BSA-Ag liposomes with coentrapped adamantylamide dipeptide (AdDP) was comparable with that of FCA in terms of longevity and levels of specific antibodies in mouse sera.

引用

页码：157 / 161

页数：5

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