A PORCINE GUT POLYPEPTIDE IDENTICAL TO THE PANCREATIC HORMONE PP (PANCREATIC-POLYPEPTIDE)

被引：11
作者：
CHEN, ZW
BERGMAN, T
OSTENSON, CG
HOOG, A
NASLUND, J
NORBERG, A
CARLQUIST, M
EFENDIC, S
MUTT, V
JORNVALL, H
机构：
[1] KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS,S-17177 STOCKHOLM,SWEDEN
[2] KAROLINSKA HOSP,DEPT ENDOCRINOL & CLIN GENET,S-17176 STOCKHOLM,SWEDEN
[3] KAROLINSKA HOSP,DEPT ALCOHOL & DRUG ADDICT RES,S-17176 STOCKHOLM,SWEDEN
[4] KAROLINSKA HOSP,DEPT PATHOL,S-17176 STOCKHOLM,SWEDEN
[5] KARO BIO AB,S-14104 HUDDINGE,SWEDEN
来源：
FEBS LETTERS | 1994年 / 341卷 / 2-3期
关键词：
PANCREATIC HORMONE; PANCREATIC POLYPEPTIDE; PIG INTESTINE; RADIOIMMUNOASSAY; IMMUNOHISTOCHEMISTRY;
D O I：
10.1016/0014-5793(94)80464-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A peptide hormone has been isolated from porcine intestine. Its primary structure was found to consist of 36 amino acid residues in a sequence identical to that of the porcine pancreatic polypeptide, previously not isolated from intestines or a tissue other than pancreas. The gut polypeptide significantly suppresses glucose-induced insulin secretion in vitro. Using an immunohistochemical technique, we also identified cells in the porcine gastrointestinal tract that were immunoreactive with pancreatic polypeptide. The immunoreactivity disappeared after absorption with the isolated gut polypeptide or synthetic human pancreatic polypeptide.
引用
收藏
页码：239 / 243
页数：5
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