THE ZFH-2 GENE-PRODUCT IS A POTENTIAL REGULATOR OF NEURON-SPECIFIC DOPA DECARBOXYLASE GENE-EXPRESSION IN DROSOPHILA

被引:63
作者
LUNDELL, MJ
HIRSH, J
机构
[1] Department of Biology, University of Virginia, Charlottesville
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0012-1606(92)90050-Q
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have studied a 40-bp upstream regulatory region of the DOPA decarboxylase gene (Ddc) which is important for cell-specific expression in the Drosophila central nervous system (CNS). This region contains two redundant elements which when simultaneously mutated result in lowered DDC expression in serotonin neurons. We uncovered a protein binding site within one of these elements and have cloned a factor which binds to the site. This factor is the product of the zfh-2 gene, a complex homeodomain/zinc finger protein previously identified by binding to an opsin regulatory element. The in vivo profile of ZFH-2 in the larval CNS shows intriguing overlap with DDC in specific serotonin and dopamine neurons. We show that ZFH-2 is related to a human transcription factor ATBF1. The multiple homeodomain and zinc finger motifs in these two proteins show a similar linear arrangement which implies coordinate action among the motifs. In addition, the homology defines a new homeodomain subtype. © 1992.
引用
收藏
页码:84 / 94
页数:11
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