LACK OF MAJOR OLFACTORY DYSFUNCTION IN MPTP-INDUCED PARKINSONISM

被引：84
作者：
DOTY, RL
SINGH, A
TETRUD, J
LANGSTON, JW
机构：
[1] CALIF PARKINSONS FDN,SAN JOSE,CA
[2] UNIV PENN,SCH MED,DEPT OTORHINOLARYNGOL HEAD & NECK SURG,CTR SMELL & TASTE,PHILADELPHIA,PA 19104
[3] UNIV PENN,SCH MED,DEPT PHYSIOL,PHILADELPHIA,PA 19104
来源：
ANNALS OF NEUROLOGY | 1992年 / 32卷 / 01期
关键词：
D O I：
10.1002/ana.410320116
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The olfactory function of 6 patients whose parkinsonism was the result of intravenous administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was compared to that of 12 age-matched patients with idiopathic Parkinson's disease (PD) and 10 age-matched normal control subjects. Unlike their PD counterparts, the olfactory test scores of patients with MPTP-induced parkinsonism did not differ significantly from those of control subjects. These findings suggest that MPTP-induced parkinsonism, unlike idiopathic PD, is unaccompanied, on average, by major alterations in the ability to smell.
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页码：97 / 100
页数：4
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