COMPARISON OF THE PRESSOR EFFECTS OF ANGIOTENSIN-II AND ANGIOTENSIN-III IN THE ROSTRAL VENTROLATERAL MEDULLA

被引：17

作者：

SASAKI, S ^{[1
]}

LI, YW ^{[1
]}

DAMPNEY, RAL ^{[1
]}

机构：

[1] UNIV SYDNEY, DEPT PHYSIOL, SYDNEY, NSW 2006, AUSTRALIA

来源：

BRAIN RESEARCH | 1993年 / 600卷 / 02期

基金：

英国医学研究理事会;

关键词：

ANGIOTENSIN; AMASTATIN; BESTATIN; ROSTRAL VENTROLATERAL MEDULLA; BLOOD PRESSURE;

D O I：

10.1016/0006-8993(93)91393-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microinjection of angiotensin II and III into the rostral ventrolateral medulla of anesthetized barodenervated rabbits elicited in both cases pressor responses, which were of similar magnitude and time course. The responses to angiotensin II and III were either unchanged or increased in the presence of compounds which inhibit their degradation to shorter length peptides. The results indicate that both angiotensin peptides are independently capable of eliciting pressor responses in the rostral ventrolateral medulla.

引用

页码：335 / 338

页数：4

共 22 条

[11] A HYPOTHESIS REGARDING THE FUNCTION OF ANGIOTENSIN PEPTIDES IN THE BRAIN [J].

FERRARIO, CM ;

SANTOS, RAS ;

BROSNIHAN, KB ;

BLOCK, CH ;

SCHIAVONE, MT ;

KHOSLA, MC ;

GREENE, LJ .

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1988, 10 :107-121

[12] AUTORADIOGRAPHIC LOCALIZATION OF SUBTYPES OF ANGIOTENSIN-II ANTAGONIST BINDING IN THE RAT-BRAIN [J].

GEHLERT, DR ;

GACKENHEIMER, SL ;

SCHOBER, DA .

NEUROSCIENCE, 1991, 44 (02) :501-514

[13] ANGIOTENSINS - A FAMILY THAT GROWS FROM WITHIN [J].

GOODFRIEND, TL .

HYPERTENSION, 1991, 17 (02) :139-140

[14] ANGIOTENSIN-SENSITIVE NEURONS IN THE RAT PARAVENTRICULAR NUCLEUS - RELATIVE POTENCIES OF ANGIOTENSIN-II AND ANGIOTENSIN-III [J].

HARDING, JW ;

FELIX, D .

BRAIN RESEARCH, 1987, 410 (01) :130-134

[15] THE EFFECTS OF THE AMINOPEPTIDASE INHIBITORS AMASTATIN AND BESTATIN ON ANGIOTENSIN-EVOKED NEURONAL-ACTIVITY IN RAT-BRAIN [J].

HARDING, JW ;

FELIX, D .

BRAIN RESEARCH, 1987, 424 (02) :299-304

[16] INCREASED BLOOD-PRESSURE INDUCED BY CENTRAL APPLICATION OF AMINOPEPTIDASE INHIBITORS IS ANGIOTENSINERGIC-DEPENDENT IN NORMOTENSIVE AND HYPERTENSIVE RAT STRAINS [J].

JENSEN, LL ;

HARDING, JW ;

WRIGHT, JW .

BRAIN RESEARCH, 1989, 490 (01) :48-55

[17] LOCALIZATION OF ANGIOTENSIN-II RECEPTOR-BINDING IN RABBIT BRAIN BY INVITRO AUTORADIOGRAPHY [J].

MENDELSOHN, FAO ;

ALLEN, AM ;

CLEVERS, J ;

DENTON, DA ;

TARJAN, E ;

MCKINLEY, MJ .

JOURNAL OF COMPARATIVE NEUROLOGY, 1988, 270 (03) :372-384

[18]

REIS DJ, 1988, HYPERTENSION, V11, P8

[19] INHIBITION OF AMINOPEPTIDASES BY AMASTATIN AND BESTATIN DERIVATIVES - EFFECT OF INHIBITOR STRUCTURE ON SLOW-BINDING PROCESSES [J].

RICH, DH ;

MOON, BJ ;

HARBESON, S .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (04) :417-422

[20] TONIC CARDIOVASCULAR EFFECTS OF ANGIOTENSIN-II IN THE VENTROLATERAL MEDULLA [J].

SASAKI, S ;

DAMPNEY, RAL .

HYPERTENSION, 1990, 15 (03) :274-283

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