MECHANISM OF ANTIINFLAMMATORY ACTION OF GLYCYRRHIZIN - EFFECT ON NEUTROPHIL FUNCTIONS INCLUDING REACTIVE OXYGEN SPECIES GENERATION

被引:117
作者
AKAMATSU, H [1 ]
KOMURA, J [1 ]
ASADA, Y [1 ]
NIWA, Y [1 ]
机构
[1] KANSAI MED UNIV, DEPT DERMATOL, FUMIZONO CHO, MORIGUCHI, OSAKA 570, JAPAN
关键词
GLYCYRRHIZA GLABRA; GLYCYRRHIZIN; ANTIINFLAMMATORY ACTIVITY; REACTIVE OXYGEN SPECIES; NEUTROPHIL FUNCTIONS;
D O I
10.1055/s-2006-960045
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The effect of glycyrrhizin on inflammatory mediators such as neutrophil functions including reactive oxygen species (ROS) generation was examined. Glycyrrhizin significantly decreased neutrophil-generated O2-, H2O2 and OH in a dose-dependent manner. However, the drug did not reduce any of the ROS generated in a cell-free, xanthine-xanthine oxidase system. The drug did not affect neutrophil chemotaxis or phagocytosis, either. The present study indicates that glycyrrhizin is not an ROS scavenger but exerts an anti-inflammatory action by inhibiting the generation of ROS by neutrophils, the most potent inflammatory mediator at the site of inflammation.
引用
收藏
页码:119 / 121
页数:3
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