ESR SPECTROSCOPY OF FLOW-ORIENTED CATION RADICALS OF PHENOTHIAZINE-DERIVATIVES AND PHENOXATHIIN INTERCALATED IN DNA

被引:18
|
作者
STOLZE, K [1 ]
MASON, RP [1 ]
机构
[1] NIEHS,MOLEC BIOPHYS LAB,POB 12233,RES TRIANGLE PK,NC 27709
关键词
ELECTRON SPIN RESONANCE; DNA; PHENOTHIAZINE; PHENOXATHIIN; FREE RADICALS; INTERCALATION;
D O I
10.1016/0009-2797(91)90037-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several derivatives of the phenothiazine cation radicals intercalated into DNA have been investigated using a new flow orientation technique. The anistropic hyperfine coupling constants of both the parallel and the perpendicular orientation relative to the magnetic field were measured and compared to previous results, which used different techniques. The phenoxathiin cation radical could also be stabilized by intercalation into DNA at pH 4, but the orientation technique revealed no further information due to the poor resolution of the experimental spectra.
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页码:283 / 289
页数:7
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