THE DIOXIN AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS - NUCLEAR RECEPTORS IN SEARCH OF ENDOGENOUS LIGANDS

被引：96
作者：
POELLINGER, L
GOTTLICHER, M
GUSTAFSSON, JA
机构：
[1] Karolinska Institutet, Huddinge University Hospital F-60, S-141 86 Huddinge, Novum
[2] M. Gö, Karolinska Institutet, Huddinge University Hospital F-60, S-141 86 Huddinge, Novum
[3] Karolinska Institutet, Huddinge University Hospital F-60, S-141 86 Huddinge, Novum
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1992年 / 13卷 / 06期
关键词：
D O I：
10.1016/0165-6147(92)90076-I
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dioxins and peroxisome proliferators represent two diverse classes of xenobiotic compounds that induce transcription of specific genes encoding cytochrome P-450 drug-metabolizing enzymes. Signal transduction by these chemicals is mediated by two distinct nuclear receptors, one of which has recently been demonstrated to be a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. However, no endogenous ligand has so far been identified for either of these nuclear receptors. Lorenz Poellinger, Martin Gottlicher and Jan-Ake Gustafsson review properties of both these xenobiotic receptor systems and discuss how the molecular details in the receptor activation pathways compare with those of nuclear hormone receptors.
引用
收藏
页码：241 / 245
页数：5
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