SOLID-PHASE EXTRACTION AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF DOXOPHYLLINE IN PLASMA

被引：15
|
作者：
LAGANA, A [1 ]
BIZZARRI, M [1 ]
MARINO, A [1 ]
MANCINI, M [1 ]
机构：
[1] UNIV ROME LA SAPIENZA,DEPT CARDIAC SURG,I-00185 ROME,ITALY
来源：
BIOMEDICAL CHROMATOGRAPHY | 1990年 / 4卷 / 05期
关键词：
D O I：
10.1002/bmc.1130040507
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A sensitive and selective high performance liquid chromatographic doxophylline assay with ultraviolet detection has been developed for plasma samples. The drug is isolated from biological samples with a reversed phase C18 disposable extraction column. Plasma standard curves are linear for concentrations of doxophylline from 0.03 to 10 mg/L. At the therapeutic range concentrations, the recoveries are better than 96.9%. The coefficients of variation for the procedure are 4.1% and 2.7% for the concentrations 0.03 mg/L and 10 mg/L, respectively. By this method, pharmacokinetic profiles are obtained for six adult volunteers. Copyright © 1990 John Wiley & Sons, Ltd.
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页码：205 / 207
页数：3
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