Single-nucleotide polymorphism (c.309T>G) in the MDM2 gene and lung cancer risk

被引：9

作者：

Enokida, Yasuaki ^{[1
]}

Shimizu, Kimihiro ^{[1
]}

Kakegawa, Seiichi ^{[1
]}

Atsumi, Jun ^{[1
]}

Takase, Yoshiaki ^{[1
]}

Miyamae, Yohei ^{[1
]}

Nagashima, Toshiteru ^{[1
]}

Ohtaki, Yoichi ^{[1
]}

Kaira, Kyoichi ^{[2
]}

Sunaga, Noriaki ^{[3
]}

Yanagitani, Noriko ^{[3
]}

Yoshino, Reiko ^{[4
]}

Tsunekawa, Katsuhiko ^{[5
]}

Igai, Hitoshi ^{[6
]}

Kamiyoshihara, Mitsuhiro ^{[6
]}

Usui, Kengo ^{[7
]}

Lezhava, Alexander ^{[7
]}

Tomizawa, Yoshio ^{[4
]}

Ishikawa, Toshihisa ^{[8
]}

Murakami, Masami ^{[5
]}

Hayashizaki, Yoshihide ^{[9
]}

Takeyoshi, Izumi ^{[1
,2
,3
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Thorac & Visceral Organ Surg, 3-39-15 Showa Machi, Maebashi, Gunma 3718511, Japan

[2] Gunma Univ, Grad Sch Med, Dept Oncol Clin Dev, Maebashi, Gunma 3718511, Japan

[3] Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, Japan

[4] Natl Hosp Org Nishi Gunma Hosp, Dept Internal Med, Shibukawa, Gunma 3778511, Japan

[5] Gunma Univ, Dept Clin Lab Med, Grad Sch Med, Maebashi, Gunma 3718511, Japan

[6] Maebashi Red Cross Hosp, Dept Gen Thorac Surg, Maebashi, Gunma 3710014, Japan

[7] RIKEN, Ctr Life Sci Technol, Div Genom Technol, Yokohama, Kanagawa 2300045, Japan

[8] NGO Personalized Med & Healthcare, Yokohama, Kanagawa 2260016, Japan

[9] RIKEN, Prevent Med & Diag Innovat Program, Yokohama, Kanagawa 2300045, Japan

来源：

BIOMEDICAL REPORTS | 2014年 / 2卷 / 05期

基金：

日本学术振兴会;

关键词：

lung cancer; murine double minute 2; p53; single-nucleotide polymorphism 309; smart amplification process; smoking history; cancer susceptibility;

D O I：

10.3892/br.2014.305

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Murine double minute 2 (MDM2) is a negative regulator of p53. A single-nucleotide polymorphism (SNP) (rs2279744: c.309T>G) in the promoter region of the MDM2 gene has been shown to result in higher levels of MDM2 RNA and protein. Regarding the contribution of c.309T>G in the MDM2 gene to the lung cancer risk, previous studies are conflicting. In order to evaluate the association between c.309T>G and the lung cancer risk, a case-control study was performed. The MDM2 genotypes were determined in 762 lung cancer patients and in 700 cancer-free control subjects using the Smart Amplification Process. Statistical adjustment was performed for gender, age and pack-years of smoking. The distributions of c.309T>G (T/T, T/G, G/G) were 20.1, 49.7, 30.2% in the case group and 21.7, 47.9, 30.4% in the healthy-control group. There were no overall associations between the MDM2 genotypes and the risk of lung cancer [T/G genotype: Adjusted odds ratio (AOR), 1.30; 95% confidence

引用

页码：719 / 724

页数：6

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