COMPARATIVE-EVALUATION OF CONVENTIONAL 5 MM INVERSE AND MICRO INVERSE DETECTION PROBES AT 500 MHZ

Performance and sensitivity characteristics of a standard 5 mm inverse detection probe and a new micro inverse detection probe design were compared on identical amounts of material at 500 MHz. The latter consistently afforded approximately twice the signal-to-noise performance of the former in two-dimensional experiments, corresponding to a factor of four improvement in performance times to obtain comparable signal-to-noise ratio projections of HMQC data. The latter also facilitated the acquisition of HMQC spectra on much smaller amounts of material than was possible in the conventional 5 mm inverse detection probe.