STRUCTURE, SYNTHESIS, AND ANTITUMOR-ACTIVITY OF THE HYDROLYSIS PRODUCT OF THE ANTITUMOR AGENT CARMETHIZOLE

被引：0

作者：

ANDERSON, WK ^{[1
]}

HOUSTON, DM ^{[1
]}

JAROSINSKI, MA ^{[1
]}

KINDER, FR ^{[1
]}

KODE, RN ^{[1
]}

VANROEY, P ^{[1
]}

SALERNO, JM ^{[1
]}

机构：

[1] MED FDN BUFFALO INC, BUFFALO, NY USA

来源：

DRUG DEVELOPMENT RESEARCH | 1993年 / 30卷 / 03期

关键词：

CARMETHIZOLE; ANTICANCER; TOXICITY; HYDROLYSIS;

D O I：

10.1002/ddr.430300306

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X-ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monocarbamates, 2b and 2c, were compared with 1. (C) 1993 Wiley-Liss, Inc.

引用

页码：143 / 146

页数：4

共 11 条

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