P53 MUTATION IN HUMAN HEPATOCELLULAR-CARCINOMA IN INDIA

被引：0
|
作者：
SAHOO, T
RAMAKRISHNA, B
HABIBULLAH, CM
PATIL, DN
DAS, MR
机构：
[1] CHRISTIAN MED COLL & HOSP,DEPT PATHOL,VELLORE 632004,TAMIL NADU,INDIA
[2] OSMANIA GEN HOSP,DEPT GASTROENTEROL,HYDERABAD 500001,INDIA
来源：
CURRENT SCIENCE | 1993年 / 65卷 / 07期
关键词：
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have analysed a number of primary hepatocellular carcinomas (HCC), both fresh and paraffin-embedded tissues, for the presence of a hotspot mutation in p53 at the 249th codon of exon 7. Of the samples analysed, ten were found to be hepatitis-B antigen-positive and one among them showed the hotspot mutation. We have shown that paraffin-embedded samples can easily be used for PCR analysis of mutations. Our results show that alteration in this mutational hotspot is not very frequent in Indian HCC cases similar to the situation obtained in Australia and Taiwan and that hepatitis B virus infection cannot be a major factor for alteration in the 249th codon of exon 7 in p53.
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页码：554 / 557
页数：4
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