INHIBITION OF TRANSCRIPTION BY MAMMALIAN RIBONUCLEIC-ACID POLYMERASE-II - EFFECTS OF DIETHYLSTILBESTROL AND ITS ANALOGS

被引：0

作者：

ODA, T ^{[1
]}

SATO, Y ^{[1
]}

KITAJIMA, S ^{[1
]}

YASUKOCHI, Y ^{[1
]}

机构：

[1] TOKYO MED & DENT UNIV, INST MED RES, BUNKYO KU, TOKYO 113, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 10期

关键词：

TRANSCRIPTION; RNA POLYMERASE-II; DIETHYLSTILBESTROL; INDENESTROL-A; INDENESTROL-B; ESTRADIOL; DIENESTROL;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We examined the effects of diethylstilbestrol (1) Z,Z-dienestrol (2), E,E-dienestrol (3), indenestrol A (4), indenestrol B (5) and estradiol (6) on the activity of in vitro accurate transcription from adenovirus 2 major late promoter by mammalian ribonucleic acid (RNA) polymerase II using partially purified transcription factors from HeLa cell nuclear extract as well as on RNA polymerase II activity assayed for random incorporation of ribonucleotides. 1, 2, and 3 inhibited both activities, whereas 4 and 5 were inhibitory only in the transcription activity at concentrations higher than 10-mu-g/ml. However 6 had no effects on both activities.

引用

页码：2627 / 2629

页数：3

共 28 条

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