EFFECT OF AGING ON PROGESTERONE-POLYOXYETHYLENE GLYCOL 6000 DISPERSIONS - X-RAY STUDY

被引：10

作者：

DUCLOS, R ^{[1
]}

GRENET, J ^{[1
]}

SAITER, JM ^{[1
]}

BESANCON, P ^{[1
]}

ORECCHIONI, AM ^{[1
]}

机构：

[1] UER SCI & TECH ROUEN, LECAP LAB, F-76130 MT ST AIGNAN, FRANCE

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 02期

关键词：

D O I：

10.3109/03639049009114884

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Progesterone solid dispersions in polyoxyéthylene glycol 6000 were prepared by fusion method in order to improve the progesterone wettability and solubility in aqueous body fluids. Its crystalline state after fusion was determined by radiocrystallography on the pure drug and on the solidified melts. It has been established that a slow cooling speed of the melt induced the stable polymorph emergence in the solidified melt (α form). Moreover, X-ray diffraction patterns investigation showed a good physical stability of the preparations after one year storage at room temperature. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：255 / 265

页数：11

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