SEMISYNTHETIC CEPHALOSPORINS - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANALOGS WITH 7-ACYL GROUPS DERIVED FROM 2-(CYANOMETHYLTHIO)ACETIC ACID OR 2-[(2,2,2-TRIFLUOROETHYL)THIO]ACETIC ACID AND THEIR SULFOXIDES AND SULFONES

被引：15

作者：

DEMARINIS, RM ^{[1
]}

BOEHM, JC ^{[1
]}

DUNN, GL ^{[1
]}

HOOVER, JRE ^{[1
]}

URI, JV ^{[1
]}

GUARINI, JR ^{[1
]}

PHILLIPS, L ^{[1
]}

ACTOR, P ^{[1
]}

WEISBACH, JA ^{[1
]}

机构：

[1] SK&F LABS,DIV RES & DEV,PHILADELPHIA,PA 19101

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1977年 / 20卷 / 01期

关键词：

D O I：

10.1021/jm00211a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：30 / 35

页数：6

共 10 条

[1]

BAIN BM, 1970, Patent No. 755505

[2]

BREUER H, 1975, 9TH INT C CHEM LOND

[3] NEW PARENTERAL CEPHALOSPORIN - SK+F 59962 - 7-TRIFLUOROMETHYLTHIOACETAMIDO-3-(1-METHYL-1H-TETRAZOL-5-YLTHIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID - CHEMISTRY AND STRUCTURE ACTIVITY RELATIONSHIPS [J].

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DUNN, GL ;

ACTOR, P ;

URI, JV ;

WEISBACH, JA .

JOURNAL OF ANTIBIOTICS, 1975, 28 (06) :463-470

[4] SEMISYNTHETIC CEPHALOSPORINS - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 7-SULFONYLACETAMIDO-3-CEPHEM-4-CARBOXYLIC ACIDS [J].

DEMARINIS, RM ;

HOOVER, JRE ;

LAM, LL ;

URI, JV ;

GUARINI, JR ;

PHILLIPS, L ;

ACTOR, P ;

WEISBACH, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (06) :754-759

[5]

DERSCH F, 1949, Patent No. 2465149

[6] DARSTELLUNG UND EIGENSCHAFTEN DES 1.2.4- UND DES 1.3.4-THIODIAZOLS [J].

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OHM, J ;

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CHEMISCHE BERICHTE-RECUEIL, 1956, 89 (06) :1534-1543

[7]

KNUSEL F, 1971, ANTIMICROB AGENTS CH, P140

[8] PRECLINICAL LABORATORY STUDIES WITH A NEW 7-CYANOALKYLTHIOACYLAMINO CEPHALOSPORIN - SQ-67,590 [J].

MIRAGLIA, GJ ;

BASCH, H ;

LUKASZOW, P ;

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GADEBUSCH, HH .

JOURNAL OF ANTIBIOTICS, 1976, 29 (08) :860-862

[9]

MURPHY CF, 1972, CEPHALOSPORINS PENIC, pCH4

[10] FATE AND EXCRETION OF POLYTHIAZIDE IN DOG [J].

PINSON, R ;

CHIAINI, J ;

WISEMAN, EH ;

BAUMGARTNER, D ;

SCHREIBER, EC .

JOURNAL OF MEDICINAL & PHARMACEUTICAL CHEMISTRY, 1962, 5 (03) :491-+

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