TOTAL SYNTHESIS OF (+)-LEUKOTRIENE B4 METHYL-ESTER AND ITS 5-EPIMER FROM (R)-GLYCIDOL

被引：29
作者：
AVIGNONTROPIS, M
TREILHOU, M
POUGNY, JR
FRECHARDORTUNO, I
LINSTRUMELLE, G
机构：
[1] CNRS,CTR RECH BIOCHIM & GENET CELLULAIRES,F-31062 TOULOUSE,FRANCE
[2] ECOLE NORMALE SUPER,CHIM LAB,F-75231 PARIS 05,FRANCE
来源：
TETRAHEDRON | 1991年 / 47卷 / 35期
关键词：
D O I：
10.1016/S0040-4020(01)89730-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Pd-Cu coupling reaction of a chiral hydroxy-(E,E)-iododiene with a racemic acetylenic alcohol followed by reduction of the dienyne leads to the desired (Z,E,E) geometry and allows synthesis of LTB4 and its 5-epimer after separation of diastereomers.
引用
收藏
页码：7279 / 7286
页数：8
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