PARKINSONISM-INDUCING NEUROTOXIN, N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - CHARACTERIZATION AND LOCALIZATION OF RECEPTOR-BINDING SITES IN RAT AND HUMAN-BRAIN

被引：130
作者：
JAVITCH, JA
UHL, GR
SNYDER, SH
机构：
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21205
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205
[3] JOHNS HOPKINS UNIV HOSP,DEPT NEUROL,BALTIMORE,MD 21205
[4] MASSACHUSETTS GEN HOSP,BOSTON,MA 02114
[5] HARVARD UNIV,SCH MED,HOWARD HUGHES MED INST,BOSTON,MA 02114
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1984年 / 81卷 / 14期
关键词：
D O I：
10.1073/pnas.81.14.4591
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：4591 / 4595
页数：5
相关论文
共 20 条
[1]  
Alvord E C Jr, 1974, Adv Neurol, V5, P175
[2]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[3]   ETIOLOGY OF PARKINSONS-DISEASE [J].
CALNE, DB ;
LANGSTON, JW .
LANCET, 1983, 2 (8365) :1457-1459
[4]   DEVELOPMENTS IN PHARMACOLOGY AND THERAPEUTICS OF PARKINSONISM [J].
CALNE, DB .
ANNALS OF NEUROLOGY, 1977, 1 (02) :111-119
[5]  
CHIUEH CC, 1983, PHARMACOLOGIST, V25, P131
[6]   CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].
DAVIS, GC ;
WILLIAMS, AC ;
MARKEY, SP ;
EBERT, MH ;
CAINE, ED ;
REICHERT, CM ;
KOPIN, IJ .
PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254
[7]   THE BRAIN-STEM LESIONS IN PARKINSONISM [J].
GREENFIELD, JG ;
BOSANQUET, FD .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1953, 16 (04) :213-226
[8]   NEUROTOXICITY OF THE MEPERIDINE ANALOG N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE [J].
HALLMAN, H ;
OLSON, L ;
JONSSON, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 97 (1-2) :133-136
[9]  
HEIKKILA RE, 1984, FED PROC, V43, P743
[10]   CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS [J].
LANGSTON, JW ;
BALLARD, P ;
TETRUD, JW ;
IRWIN, I .
SCIENCE, 1983, 219 (4587) :979-980
12