THE ROLE OF PHOSPHOLIPASE-A2 IN LIPID PEROXIDATION-INDUCED FALL OF MEMBRANE-POTENTIAL OF RAT-LIVER MITOCHONDRIA

被引：8
|
作者：
GOGVADZE, VG
BRUSTOVETSKY, NN
ZHUKOVA, AA
机构：
[1] Institute of Biological Physics, USSR Academy of Sciences, Pushchino
来源：
FEBS LETTERS | 1990年 / 264卷 / 02期
关键词：
Calcium; Lipid peroxidation; Mitochondria; Phospholipase A[!sub]2[!/sub;
D O I：
10.1016/0014-5793(90)80240-J
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cumene hydroperoxide (230 μM)-induced fall of the membrane potential takes place only in Ca2+ -loaded mitochondria. Inhibitor of phospholipase A2, P-bromphenacyl bromide prevents uncoupling of mitochondria, having no effect on the accumulation of lipid peroxidation products. © 1990.
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页码：168 / 170
页数：3
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