INFLUENCE OF VARIOUS CONCENTRATIONS OF TAXOL ON CELL-SURVIVAL, MICRONUCLEI INDUCTION, AND LDH ACTIVITY IN CULTURED V79 CELLS

被引：25
作者：
JAGETIA, GC
ADIGA, SK
机构：
[1] Department of Radiobiology, Kasturba Medical College, Manipal
来源：
CANCER LETTERS | 1995年 / 96卷 / 02期
关键词：
TAXOL; V79; CELLS; SURVIVAL; MICRONUCLEI; LACTATE DEHYDROGENASE;
D O I：
10.1016/0304-3835(95)03929-Q
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The clastogenic effect of various concentrations of taxol, namely 0, 10, 25, 50, 100, 250 and 500 nM was evaluated in V79 cells grown in vitro. Treatment of V79 cells with different concentrations of taxol reduced the survival in a concentration dependent manner. However, the frequency of micronuclei increased in a concentration dependent manner and the dose response was linear quadratic. Similarly, lactate dehydrogenase also increased with the increase in taxol concentration. The micronuclei and lactate dehydrogenase showed an inverse relationship with the cell survival.
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页码：195 / 200
页数：6
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