CENTRAL SYMPATHETIC CONTROL OF SPINAL ENDOTHELIN RELEASE IN THE RAT

被引：12
作者：
KNUEPFER, MM
OBRIEN, D
HOANG, D
GAN, Q
SONG, C
机构：
[1] Department of Pharmacological and Physiological Science, St. Louis University School of Medicine, St. Louis, MO 63104
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 03期
关键词：
ENDOTHELIN; RADIOIMMUNOASSAY; SPINAL CORD; SYMPATHETIC NERVOUS SYSTEM;
D O I：
10.1016/0014-2999(94)90658-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Endothelin and its receptors have been identified in the spinal cord. Intrathecal administration of endothelin-3 produces hypotension in anesthetized rats. The present study was designed to identify whether endothelin-3 is released upon changes in sympathetic nervous activity. Endothelin-3-like immunoreactivity in spinal superfusates was directly correlated with resting arterial pressure. Endothelin-3 levels were enhanced by hypothalamic stimulation and by hemorrhage-induced hypotension and reduced by nitroprusside-induced hypotension. These findings suggest that sympathetic activation enhances endothelin-3 release but that nitroprusside may act directly to suppress release. We propose that endothelin-3 plays a role in spinal regulation of sympathetic outflow.
引用
收藏
页码：305 / 308
页数：4
相关论文
共 14 条
[1]   A NOVEL NEURONAL MESSENGER MOLECULE IN BRAIN - THE FREE-RADICAL, NITRIC-OXIDE [J].
DAWSON, TM ;
DAWSON, VL ;
SNYDER, SH .
ANNALS OF NEUROLOGY, 1992, 32 (03) :297-311
[2]   ENDOTHELIN-1, AN ENDOTHELIUM-DERIVED PEPTIDE, IS EXPRESSED IN NEURONS OF THE HUMAN SPINAL-CORD AND DORSAL-ROOT GANGLIA [J].
GIAID, A ;
GIBSON, SJ ;
IBRAHIM, NBN ;
LEGON, S ;
BLOOM, SR ;
YANAGISAWA, M ;
MASAKI, T ;
VARNDELL, IM ;
POLAK, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (19) :7634-7638
[3]   CHARACTERISTICS OF ENDOTHELIN BINDING-SITES IN THE SPINAL-CORD OF SPONTANEOUSLY HYPERTENSIVE RATS [J].
GULATI, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 204 (03) :287-293
[4]   CHARACTERIZATION OF THE DEPRESSOR EFFECT OF INTRATHECAL ENDOTHELIN IN ANESTHETIZED RATS [J].
HAN, SP ;
CHEN, XL ;
WESTFALL, TC ;
KNUEPFER, MM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (05) :H1685-H1691
[5]   THE HUMAN ENDOTHELIN FAMILY - 3 STRUCTURALLY AND PHARMACOLOGICALLY DISTINCT ISOPEPTIDES PREDICTED BY 3 SEPARATE GENES [J].
INOUE, A ;
YANAGISAWA, M ;
KIMURA, S ;
KASUYA, Y ;
MIYAUCHI, T ;
GOTO, K ;
MASAKI, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2863-2867
[6]   QUANTITATIVE AUTORADIOGRAPHIC LOCALIZATION OF [I-125] ENDOTHELIN-1 BINDING-SITES IN SPINAL-CORD AND DORSAL-ROOT GANGLIA OF THE RAT [J].
KAR, S ;
CHABOT, JG ;
QUIRION, R .
NEUROSCIENCE LETTERS, 1991, 133 (01) :117-120
[7]   AUTORADIOGRAPHIC DISTRIBUTION IN RAT-TISSUES OF BINDING-SITES FOR ENDOTHELIN - A NEUROPEPTIDE [J].
KOSEKI, C ;
IMAI, M ;
HIRATA, Y ;
YANAGISAWA, M ;
MASAKI, T .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (04) :R858-R866
[8]   ABUNDANCE OF ENDOTHELIN-3 IN RAT INTESTINE, PITUITARY-GLAND AND BRAIN [J].
MATSUMOTO, H ;
SUZUKI, N ;
ONDA, H ;
FUJINO, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (01) :74-80
[9]   SPECIFIC BINDING-SITES FOR I-125 ENDOTHELIN-1 IN THE PORCINE AND HUMAN SPINAL-CORD [J].
NIWA, M ;
KAWAGUCHI, T ;
HIMENO, A ;
FUJIMOTO, M ;
KURIHARA, M ;
YAMASHITA, K ;
KATAOKA, Y ;
SHIGEMATSU, K ;
TANIYAMA, K .
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1992, 225 (04) :281-289
[10]   ENDOTHELIN-3 IS A NOVEL NEUROPEPTIDE - ISOLATION AND SEQUENCE DETERMINATION OF ENDOTHELIN-1 AND ENDOTHELIN-3 IN PORCINE BRAIN [J].
SHINMI, O ;
KIMURA, S ;
SAWAMURA, T ;
SUGITA, Y ;
YOSHIZAWA, T ;
UCHIYAMA, Y ;
YANAGISAWA, M ;
GOTO, K ;
MASAKI, T ;
KANAZAWA, I .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (01) :587-593
12