PRIMARY BILIARY-CIRRHOSIS IN HLA-IDENTICAL TWIN SISTERS

被引：0

作者：

FREEMAN, HJ

BAILEY, RJ

机构：

[1] Gastroenterology Department, ACU F-137, University Hospital, Vancouver, BC V6T 1W5

来源：

CANADIAN JOURNAL OF GASTROENTEROLOGY | 1994年 / 8卷 / 02期

关键词：

ANTIMITOCHONDRIAL ANTIBODIES; HERITABLE LIVER DISEASES; HUMAN LEUKOCYTE ANTIGENS (HLA); IDENTICAL TWINS; PRIMARY BILIARY CIRRHOSIS;

D O I：

10.1155/1994/954162

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Human leukocyte antigen (HLA)-identical twin sisters with chronic liver disease were evaluated. Both had a childhood history of transient jaundice suggestive of a possible infectious cause. Subsequent studies in both siblings at age 51 years revealed antimitochondrial antibody-positive primary biliary cirrhosis. This report documents HLA-identical twins with primary biliary cirrhosis, providing added evidence for a genetically determined abnormal immune response in this liver disorder, possibly to a specific viral or other environmental factor.

引用

页码：88 / 91

页数：4