FLUOREN-9-YLMETHYLOXYCARBONYL (FMOC) AMINO-ACID CHLORIDE AS AN EFFICIENT REAGENT FOR ANCHORING FMOC AMINO-ACID TO 4-ALKOXYBENZYL ALCOHOL RESIN

被引：11

作者：

AKAJI, K ^{[1
]}

TANAKA, H ^{[1
]}

ITOH, H ^{[1
]}

IMAI, J ^{[1
]}

FUJIWARA, Y ^{[1
]}

KIMURA, T ^{[1
]}

KISO, Y ^{[1
]}

机构：

[1] KYOTO PHARMACEUT UNIV, DEPT MED CHEM, YAMASHINA KU, KYOTO 607, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 12期

关键词：

FMOC AMINO ACID CHLORIDE; ANCHORING; 4-ALKOXYBENZYL ALCOHOL RESIN; RACEMIZATION; SUBSTITUTION LEVEL; SOLID-PHASE PEPTIDE SYNTHESIS; FMOC PROTECTION;

D O I：

10.1248/cpb.38.3471

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Esterification of Fmoc amino acids to 4-alkoxybenzyl alcohol polystyrene through acid chlorides was achieved in high yield with practically no racemization. This reaction is especially effective for the rapid anchoring of amino acids which have bulky side chains.

引用

页码：3471 / 3472

页数：2

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