Medical abortion by mifepristone with oral versus vaginal misoprostol

OBJECTIVE(S) : To compare oral with vaginal administration of misoprostol for induced abortion in women treated initially with mifepristone. METHOD(S) : We administered 200mg of mifepristone to 128 women seeking termination of pregnancy within 9 weeks of amenorrhea. Forty eight hours later, they were assigned to receive 800 ? g misoprostol either orally or vaginally. RESULTS : The complete abortion rates in vaginal group and oral group were 96.7% and 86.2% respectively. Median induction to abortion interval was significantly longer in women in the oral group compared to that in the vaginal group (P=0.04). CONCLUSION(S) : Mifepristone followed by vaginal misoprostol was more effective at inducing an abortion up to 9 weeks of pregnancy than followed by oral form.