Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity

被引：25

作者：

Guturu, Praveen ^{[1
]}

Duchini, Andrea ^{[1
]}

机构：

[1] Univ Texas Med Branch, Div Gastroenterol & Hepatol, 301 Univ Blvd, Galveston, TX 77555 USA

来源：

INTERNATIONAL JOURNAL OF HEPATOLOGY | 2012年 / 2012卷

关键词：

D O I：

10.1155/2012/212865

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Incidence of nonalcoholic fatty liver disease is increasing with an estimated prevalence of 20-30% in developed nations. This is leading to increased incidence of chronic liver disease, cirrhosis, and hepatocellular cancer. It is critical to understand the etiology and pathogenesis of any disease to create therapeutic targets and develop new treatments. In this paper we discuss the etiology and pathogenesis of nonalcoholic steatohepatitis with special focus on obesity, role of insulin resistance, and molecular mechanisms of hepatotoxicity.

引用

页数：8

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