Rosuvastatin-Induced Acute Interstitial Nephritis

被引：8

作者：

Londrino, Francesco ^{[1
]}

Zattera, Tito ^{[1
]}

Falqui, Valeria ^{[1
]}

Corbani, Valentina ^{[1
]}

Cavallini, Marco ^{[1
]}

Stefanini, Teseo ^{[2
]}

Chiappini, Nadia ^{[1
]}

Ardini, Michela ^{[1
]}

Martina, Valentina ^{[1
]}

Rombola, Giuseppe ^{[1
]}

机构：

[1] Osped S Andrea, Dept Nephrol & Dialysis, La Spezia, Italy

[2] Osped S Andrea, Dept Radiol, La Spezia, Italy

来源：

CASE REPORTS IN NEPHROLOGY AND DIALYSIS | 2013年 / 3卷 / 01期

关键词：

Rosuvastatin; Acute interstitial nephritis; Acute kidney injury;

D O I：

10.1159/000353175

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of acute interstitial nephritis (AIN), most likely induced by rosuvastatin, in an 83-year-old male patient. The patient underwent angioplasty of the left internal carotid artery, after which he began a regimen of rosuvastatin (20 mg/day). After 3 weeks the patient was admitted to our unit for acute renal failure with mild proteinuria with negligible urinary sediment. A left kidney biopsy showed dense interstitial infiltrates, mainly composed of lymphocytes with evident tubulitis. Rosuvastatin withdrawal plus prednisolone (1 mg/kg/day) treatment, which was slowly tapered over a period of 4 weeks, allowed for a complete recovery of renal function. To our knowledge, this is the first case report of rosuvastatininduced AIN. Acute renal failure is associated with a clear increase in morbidity, length of hospital stay and mortality. Moreover, since statins are among the most widely prescribed drugs in Western countries, we think that the risk of AIN should be taken into account as a possible side effect of rosuvastatin. (C) 2013 S. Karger AG, Basel

引用

页码：87 / 90

页数：4