EVIDENCE FOR ROLE OF M-7G-5'-PHOSPHATE GROUP IN RECOGNITION OF EUKARYOTIC MESSENGER-RNA BY INITIATION-FACTOR IF-M3

被引：147
作者：
SHAFRITZ, DA
WEINSTEIN, JA
SAFER, B
MERRICK, WC
WEBER, LA
HICKEY, ED
BAGLIONI, C
机构：
[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10461 USA
[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT CELL BIOL, BRONX, NY 10461 USA
[3] NHLI, MOLEC HEMATOL BRANCH, BETHESDA, MD 20014 USA
[4] SUNY ALBANY, DEPT BIOL SCI, ALBANY, NY 12222 USA
来源：
NATURE | 1976年 / 261卷 / 5558期
关键词：
D O I：
10.1038/261291a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
7-Methylguanosine 5''-monophosphate inhibits protein synthesis in a fractionated, messenger-dependent rabbit reticulocyte cell-free system. This compound also inhibits binding of histone mRNA to reticulocyte ribosomes and interaction of VSV [vesicular stomatitis virus] mRNA and histone mRNA but not EMC [encephalomyocarditis] virus RNA with purified initiation factor IF-M3. These studies provide evidence that the role of 7-methylguanosine in the mechanism for initiation of eukaryotic mRNA translation may be related to specific recognition of mRNA by initiation factor IF-M3.
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收藏
页码：291 / 294
页数：4
相关论文
共 37 条
[11]  
FELLNER P, 1975, 3RD INT C VIR, P161
[12]   METHYLATED, BLOCKED 5' TERMINI IN HELA-CELL MESSENGER-RNA [J].
FURUICHI, Y ;
MORGAN, M ;
SHATKIN, AJ ;
JELINEK, W ;
SALDITTGEORGIEFF, M ;
DARNELL, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (05) :1904-1908
[13]   5'-TERMINAL M7G(5')PPP(5')GMP INVIVO - IDENTIFICATION IN REOVIRUS GENOME RNA [J].
FURUICHI, Y ;
MUTHUKRISHNAN, S ;
SHATKIN, AJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (02) :742-745
[14]   BLOCKED STRUCTURE AT 5' TERMINUS OF MESSENGER-RNA FROM CYTOPLASMIC POLYHEDROSIS-VIRUS [J].
FURUICHI, Y ;
MIURA, KI .
NATURE, 1975, 253 (5490) :374-375
[15]   SUBCELLULAR-LOCALIZATION OF VESICULAR STOMATITIS-VIRUS MESSENGER-RNAS [J].
GRUBMAN, MJ ;
MOYER, SA ;
BANERJEE, AK ;
EHRENFELD, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 62 (03) :531-538
[16]  
GUPTA NK, 1973, J BIOL CHEM, V248, P4500
[17]   INTERACTION OF POLY(A) AND MESSENGER-RNA WITH EUKARYOTIC INITIATOR MET-TRANSFER-RNAF BINDING FACTOR - IDENTIFICATION OF THIS ACTIVITY ON RETICULOCYTE RIBONUCLEIC-ACID PROTEIN PARTICLES [J].
HELLERMAN, JG ;
SHAFRITZ, DA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (03) :1021-1025
[18]   INHIBITION OF INITIATION OF PROTEIN-SYNTHESIS BY 7-METHYLGUANOSINE-5'-MONOPHOSPHATE [J].
HICKEY, ED ;
WEBER, LA ;
BAGLIONI, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (01) :19-23
[19]   STUDIES ON TRANSLATIONAL CONTROL OF HISTONE SYNTHESIS .1. TRANSLATION OF HISTONE MESSENGER-RNA BY HETEROLOGOUS CELL-FREE SYSTEMS PREPARED FROM CELLS INACTIVE IN DNA-SYNTHESIS [J].
JACOBSLORENA, M ;
GABRIELLI, F ;
BORUN, TW ;
BAGLIONI, C .
BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 324 (02) :275-281
[20]   IDENTIFICATION AND RNA-BINDING PROPERTIES OF AN INITIATION-FACTOR CAPABLE OF RELIEVING TRANSLATIONAL INHIBITION INDUCED BY HEME DEPRIVATION OR DOUBLE-STRANDED-RNA [J].
KAEMPFER, R .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 61 (02) :591-597
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