EVIDENCE FOR ROLE OF M-7G-5'-PHOSPHATE GROUP IN RECOGNITION OF EUKARYOTIC MESSENGER-RNA BY INITIATION-FACTOR IF-M3

被引：147

作者：

SHAFRITZ, DA

WEINSTEIN, JA

SAFER, B

MERRICK, WC

WEBER, LA

HICKEY, ED

BAGLIONI, C

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10461 USA

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT CELL BIOL, BRONX, NY 10461 USA

[3] NHLI, MOLEC HEMATOL BRANCH, BETHESDA, MD 20014 USA

[4] SUNY ALBANY, DEPT BIOL SCI, ALBANY, NY 12222 USA

来源：

NATURE | 1976年 / 261卷 / 5558期

关键词：

D O I：

10.1038/261291a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

7-Methylguanosine 5''-monophosphate inhibits protein synthesis in a fractionated, messenger-dependent rabbit reticulocyte cell-free system. This compound also inhibits binding of histone mRNA to reticulocyte ribosomes and interaction of VSV [vesicular stomatitis virus] mRNA and histone mRNA but not EMC [encephalomyocarditis] virus RNA with purified initiation factor IF-M3. These studies provide evidence that the role of 7-methylguanosine in the mechanism for initiation of eukaryotic mRNA translation may be related to specific recognition of mRNA by initiation factor IF-M3.

引用

页码：291 / 294

页数：4

共 37 条

[1] NOVEL INITIATION OF RNA-SYNTHESIS INVITRO BY VESICULAR STOMATITIS-VIRUS [J].