Genetic predisposition markers for prostate cancer

被引：0
作者：
Kanaeva, M. D. [1 ]
Vorobtsova, I. E. [1 ]
机构：
[1] Minist Hlth Russia, Russian Res Ctr Radiol & Surg Technol, 70 Leningradskaya St, St Petersburg 197758, Russia
来源：
ONKOUROLOGIYA | 2015年 / 11卷 / 03期
关键词：
prostate cancer; genetic predisposition; familial analysis; twin study; segregation analysis; mapping; molecular genetic markers; gene mutations; rare germline mutations; highly penetrant genes; polymorphic variants; lowly penetrant genes; risk of cancer;
D O I：
10.17650/1726-9776-2015-11-3-16-23
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate cancer (PC), like most cancers, belongs to multifactorial diseases arising from an interaction between environmental factors and an individual's genotype. The paper reviews the literature on the genetic predisposition to PC, which is determined by both rare gene mutations with high penetrance and inherited polymorphic genetic variants with low penetrance. The paper considers the clinical aspects of genetic predisposition to PC, among other factors, the need for male screening for both types of genetic abnormalities to assess the risk of this cancer.
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收藏
页码：16 / 23
页数：8
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