EFFECT OF SELENIUM SUPPLEMENTATION ON SOME BLOOD BIOCHEMICAL PARAMETERS IN MALE-RATS

被引：16

作者：

CRESPO, AMV ^{[1
]}

LANCA, MJ ^{[1
]}

VASCONCELOS, S ^{[1
]}

ANDRADE, V ^{[1
]}

RODRIGUES, H ^{[1
]}

SANTOS, MC ^{[1
]}

机构：

[1] FAC CIENCIAS LISBOA,DEPT QUIM,LISBON,PORTUGAL

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1995年 / 47卷 / 1-3期

关键词：

RAT; SELENIUM; GLUTATHIONE PEROXIDASE; PEROXIDATION INDEX; CHOLESTEROL; TRIGLYCERIDES; PHOSPHOLIPIDS;

D O I：

10.1007/BF02790136

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The long-term effect of selenium supplementation on blood glutathione peroxidase (GSH-Px) activity and plasma TBARS' production (as an index of peroxidation) was evaluated in 15-mo-old male rats fed a diet supplemented with 0.25 or 0.50 ppm selenium, for 12 mo. A group of nonsupplemented age-matched rats was the control. In addition, triglycerides, phospholipids, total and free cholesterol, HDL-cholesterol, and HDL-phospholipids levels were measured in plasma. Plasma testosterone levels were also determined in order to control the aging process in these animals. The GSH-Px activity and the peroxidation level were unchanged in all the groups. However, concerning the lipid parameters, a decrease in triglycerides concentration was observed in both treated groups (p < 0.05). Therefore, in these experimental conditions, despite no observed changes in parameters related to lipid peroxidation, selenium seems to be involved with triglycerides metabolism, eventually improving the triglycerides status of aged animals.

引用

页码：343 / 347

页数：5

共 14 条

[1] EVIDENCE FOR SPECIFIC SELENIUM TARGET TISSUES AND NEW BIOLOGICALLY IMPORTANT SELENOPROTEINS [J].