GLIAL-CELLS OF THE OLIGODENDROCYTE LINEAGE EXPRESS BOTH KAINATE-PREFERRING AND AMPA-PREFERRING SUBTYPES OF GLUTAMATE-RECEPTOR

被引：287
作者：
PATNEAU, DK
WRIGHT, PW
WINTERS, C
MAYER, ML
GALLO, V
机构：
[1] Laboratory of Cellular, Molecular Neurophysiology NICHD National Institutes of Health Bethesda
来源：
NEURON | 1994年 / 12卷 / 02期
关键词：
D O I：
10.1016/0896-6273(94)90277-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for GluR6, GluR7, KA-1, and KA-2, rapidly desensitizing responses to AMPA, and mRNAs for CluR-B, -C, and -D. Analysis of glutamate receptor currents in single cells reveals two receptor populations with high and low affinity for kainate and different sensitivity for potentiation by concanavalin A and for block of desensitization by cyclothiazide. Our experiments describe the characterization of native kainate-preferring receptors in glia and reveal coexpression in single cells of functional AMPA- and kainate-preferring receptors.
引用
收藏
页码：357 / 371
页数：15
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