A MODEL FOR DETERMINING IMMUNOGENIC RELATIONSHIPS BETWEEN AVIAN INFECTIOUS-BRONCHITIS VIRUSES

被引：8

作者：

ARVIDSON, Y

TANNOCK, GA

SENTHILSELVAN, A

ZERBES, M

机构：

[1] Faculty of Medicine, The University of Newcastle

来源：

ARCHIVES OF VIROLOGY | 1990年 / 111卷 / 3-4期

关键词：

D O I：

10.1007/BF01311056

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A model for determining immunogenic relationships between strains of infectious bronchitis virus is described that is based upon the vaccinating dose required to induce prevention of multiplication of a standard challenge dose of an homologous strain in the lungs of specific-pathogen-free chickens. The model has been used to demonstrate that: (1) Approximately 100 times the vaccinating dose must be used to produce immunity from one compared with two doses; (2) differences of immunogenicity of >1,000-fold exist between Australian strains; (3) immunogenicity is greatest for live virus administered directly to the trachea, followed by live virus administered by the ocular route, inactivated virus administered intratracheally and inactivated virus administered intramuscularly; (4) for chickens inoculated with Australian vaccine strains, protection against challenge is unrelated to serotype. © 1990 Springer-Verlag.

引用

页码：227 / 238

页数：12

共 17 条

[1] LARGE-QUANTITY PRODUCTION OF CHICKEN EMBRYO TRACHEAL ORGAN CULTURES AND USE IN VIRUS AND MYCOPLASMA STUDIES [J].