DESIGN OF POTENTIAL ANTICONVULSANT AGENTS - MECHANISTIC CLASSIFICATION OF GABA AMINOTRANSFERASE INACTIVATORS

被引：76
作者：
NANAVATI, SM
SILVERMAN, RB
机构：
[1] NORTHWESTERN UNIV,DEPT CHEM,EVANSTON,IL 60208
[2] NORTHWESTERN UNIV,DEPT BIOCHEM MOLEC BIOL & CELL BIOL,EVANSTON,IL 60208
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 11期
关键词：
D O I：
10.1021/jm00131a001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：2413 / 2421
页数：9
相关论文
共 57 条
[1]   4-AMINO-4,5-DIHYDROTHIOPHENE-2-CARBOXYLIC ACID [J].
ADAMS, JL ;
CHEN, TM ;
METCALF, BW .
JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (15) :2730-2736
[2]  
Alston T A, 1987, J Enzyme Inhib, V1, P215, DOI 10.3109/14756368709020118
[3]   INACTIVATION OF PYRIDOXAL 5'-PHOSPHATE-DEPENDENT ENZYMES BY 5-NITRO-L-NORVALINE, AN ANALOG OF L-GLUTAMATE [J].
ALSTON, TA ;
BRIGHT, HJ .
FEBS LETTERS, 1981, 126 (02) :269-271
[4]   MECHANISM-BASED INACTIVATION OF GABA AMINOTRANSFERASE BY 3,5-DIOXOCYCLOHEXANECARBOXYLIC ACID [J].
ALSTON, TA ;
PORTER, DJT ;
WHEELER, DMS ;
BRIGHT, HJ .
BIOCHEMICAL PHARMACOLOGY, 1982, 31 (24) :4081-4084
[5]   INACTIVATION OF THE DADB SALMONELLA-TYPHIMURIUM ALANINE RACEMASE BY D-ISOMERS AND L-ISOMERS OF BETA-SUBSTITUTED ALANINES - KINETICS, STOICHIOMETRY, ACTIVE-SITE PEPTIDE SEQUENCING, AND REACTION-MECHANISM [J].
BADET, B ;
ROISE, D ;
WALSH, CT .
BIOCHEMISTRY, 1984, 23 (22) :5188-5194
[6]   SYNTHESIS OF (E)-4-AMINO-2,5-HEXADIENOIC ACID AND (E)-4-AMINO-5-FLUORO-2-PENTENOIC ACID - IRREVERSIBLE INHIBITORS OF 4-AMINOBUTYRATE-2-OXOGLUTARATE AMINOTRANSFERASE [J].
BEY, P ;
GERHART, F ;
JUNG, M .
JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (14) :2835-2838
[7]   OMEGA-FLUOROMETHYL ANALOGS OF OMEGA-AMINO ACIDS AS IRREVERSIBLE INHIBITORS OF 4-AMINOBUTYRATE-2-OXOGLUTARATE AMINOTRANSFERASE [J].
BEY, P ;
JUNG, MJ ;
GERHART, F ;
SCHIRLIN, D ;
VANDORSSELAER, V ;
CASARA, P .
JOURNAL OF NEUROCHEMISTRY, 1981, 37 (05) :1341-1344
[8]  
BIEMOND A, 1970, BRAIN DISEASES
[9]   ENANTIOSPECIFIC SYNTHESIS OF (S)-4-AMINO-4,5-DIHYDRO-2-FURANCARBOXYLIC ACID, A NEW SUICIDE INHIBITOR OF GABA-TRANSAMINASE [J].
BURKHART, JP ;
HOLBERT, GW ;
METCALF, BW .
TETRAHEDRON LETTERS, 1984, 25 (46) :5267-5270
[10]  
BURNETT A, 1979, J CHEM SOC CHEM COMM, P826
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