Development, Evaluation, and Implementation of a Pan-African Cancer Research Network: Men of African Descent and Carcinoma of the Prostate

被引：27

作者：

Andrews, Caroline ^{[1
]}

Fortier, Brian ^{[1
]}

Hayward, Amy ^{[1
]}

Lederman, Ruth ^{[1
]}

Petersen, Lindsay ^{[4
]}

McBride, Jo ^{[4
]}

Petersen, Desiree C. ^{[4
]}

Ajayi, Olabode ^{[4
]}

Kachambwa, Paidamoyo ^{[4
]}

Seutloali, Moleboheng ^{[4
]}

Shoko, Aubrey ^{[4
]}

Mokhosi, Mamokhosana ^{[4
]}

Hiller, Reinhard ^{[4
]}

Adams, Marcia ^{[9
]}

Ongaco, Chrissie ^{[9
]}

Pugh, Elizabeth ^{[9
]}

Romm, Jane ^{[9
]}

Shelford, Tarneka ^{[9
]}

Chinegwundoh, Frank ^{[11
]}

Adusei, Ben ^{[12
]}

Mante, Sunny ^{[12
]}

Snyper, Nana Yaa ^{[12
]}

Agalliu, Ilir ^{[14
]}

Lounsbury, David W. ^{[14
]}

Rohan, Thomas ^{[14
]}

Orfanos, Alex ^{[2
]}

Quintana, Yuri ^{[2
]}

Jacobson, Judith S. ^{[15
]}

Neugut, Alfred, I ^{[15
]}

Gelmann, Edward ^{[15
]}

Lachance, Joseph ^{[16
]}

Dial, Cherif ^{[18
]}

Diallo, Thierno Amadou ^{[18
]}

Jalloh, Mohamed ^{[18
]}

Gueye, Serigne Magueye ^{[18
]}

Kane, Papa Moussa Sene ^{[18
]}

Diop, Halimatou ^{[19
]}

Ndiaye, Anna Julienne ^{[19
]}

Sall, Amina Sow ^{[19
]}

Toure-Kane, Ndeye Coumba ^{[19
]}

Onyemata, Ezenwa ^{[20
]}

Abimiku, Alash'le ^{[20
]}

Adjei, Andrew A. ^{[13
]}

Biritwum, Richard ^{[13
]}

Gyasi, Richard ^{[13
]}

Kyei, Mathew ^{[13
]}

Mensah, James E. ^{[13
]}

Okine, Julian ^{[13
]}

Okyne, Vicky ^{[13
]}

Rockson, Isabella ^{[13
]}

机构：

[1] Dana Farber Canc Inst, 1101 Dana,450 Brookline Ave, Boston, MA 02115 USA

[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[3] Harvard TH Chan Sch 01 Putii Hlth, Boston, MA USA

[4] Ctr Prote & Gen uric Res, Cape Town, South Africa

[5] Stellenbosch Univ, Cape Town, South Africa

[6] Tygerberg Hosp, Cape Town, South Africa

[7] Natl Hlth Lab Serv, Natl Canc Registry, Johannesburg, South Africa

[8] Univ Witwatersrand, Johannesburg, South Africa

[9] Ctr Inherited Dis Res, Baltimore, MD USA

[10] NCI, NIH, Bethesda, MD 20892 USA

[11] Barts Hlth Natl Hlth Serv Trust, London, England

[12] 37 Mil Hosp, Accra, Ghana

[13] Korle Bu Teaching Hosp, Accra, Ghana

[14] Albert Einstein Coll Med, Bronx, NY 10467 USA

[15] Columbia Univ, New York, NY USA

[16] Georgia Inst Technol, Atlanta, GA 30332 USA

[17] Stanford Univ, Stanford Canc Inst, Stanford, CA 94305 USA

[18] Hop Gen Grand Yoff, Inst Format & Rec Urol & Sante Famillie, Dakar, Senegal

[19] Hop Aristide Le Dantec, Dakar, Senegal

[20] Inst & Human Virol, H3 African Biorepository Initiat, Abuja, Nigeria

[21] Univ Abuja, Abuja, Nigeria

[22] Univ Abuja, Teaching Hosp, Abuja, Nigeria

[23] Fed Med Ctr, Keffi, Nigeria

[24] Univ Coll Hosp, Ibadan, Nigeria

来源：

JOURNAL OF GLOBAL ONCOLOGY | 2018年 / 4卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1200/JGO.18.00063

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. Methods We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array. Results We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95% to 98% concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95% of tested DNA samples (100% from blood-derived DNA samples) with high concordance across laboratories. Conclusion We provide approaches that can produce high-quality epidemiologic and genomic data in multicenter studies of cancer in SSA. (C) 2018 by American Society of Clinical Oncology

引用

页码：1 / 14

页数：14

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