ASYMMETRIC-SYNTHESIS OF THE BETA-LACTAM FRAMEWORK VIA A 3-COMPONENT COUPLING REACTION

被引：25

作者：

ASAO, N ^{[1
]}

TSUKADA, N ^{[1
]}

YAMAMOTO, Y ^{[1
]}

机构：

[1] TOHOKU UNIV,FAC SCI,DEPT CHEM,SENDAI,MIYAGI 980,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 21期

关键词：

D O I：

10.1039/c39930001660

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of the chiral lithium amide 4 with the dienoate 5a provides regio- and stereo-selectively the beta-amino esters in essentially quantitative yield with >99% diastereolsomeric excess, which can be converted upon sequential treatment with LiNPri2-B(OMe)3-MeCHO to the key intermediate 6 for the beta-lactam 7 having the correct absolute configuration.

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页码：1660 / 1662

页数：3

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