EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS RAISES BETAINE LEVELS IN THE SPINAL-CORD OF STRAIN-13 GUINEA-PIGS

被引：17
|
作者：
PREECE, NE [1 ]
BAKER, D [1 ]
BUTTER, C [1 ]
GADIAN, DG [1 ]
URENJAK, J [1 ]
机构：
[1] ROYAL COLL SURGEONS ENGLAND, HUNTERIAN INST, DEPT PATHOL, LONDON WC2A 3PN, ENGLAND
来源：
NMR IN BIOMEDICINE | 1993年 / 6卷 / 03期
基金：
英国惠康基金;
关键词：
D O I：
10.1002/nbm.1940060305
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Chronic relapsing experimental allergic encephalomyelitis, an animal model of multiple sclerosis, was induced in Strain 13 guinea-pigs by subcutaneous injection of spinal cord homogenate and Freund's incomplete adjuvant supplemented with Mycobacterium tuberculosis. High resolution H-1 NMR spectra of CNS tissue extracts indicated that the levels of choline metabolites, particularly betaine, were elevated in the spinal cord tissue, the principal site of lesion formation in this guinea-pig strain. The spectra also show that N-acetylated compounds are slightly depleted in the disease. The results are discussed in relation to the biochemical interpretation of NMR spectra obtained in vivo from patients with multiple sclerosis.
引用
收藏
页码：194 / 200
页数：7
相关论文
共 50 条
12345