SENSITIZATION OF C-FOS EXPRESSION IN RAT STRIATUM FOLLOWING MULTIPLE CHALLENGES WITH D-AMPHETAMINE

被引：33
|
作者：
NORMAN, AB [1 ]
LU, SY [1 ]
KLUG, JM [1 ]
NORGREN, RB [1 ]
机构：
[1] UNIV CINCINNATI,DEPT ANAT & PHYSIOL,CINCINNATI,OH 45267
来源：
BRAIN RESEARCH | 1993年 / 603卷 / 01期
关键词：
ONCOPROTEIN; IMMEDIATE-EARLY RESPONSE GENE; STIMULANT; IMMUNOCYTOCHEMISTRY; CELL COUNTING; ADDICTION;
D O I：
10.1016/0006-8993(93)91308-F
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
D-Amphetamine transiently stimulates the expression of the immediate-early response gene, c-fos, in rat striatal cell nuclei. D-Amphetamine (2.5 mg/kg i.p.) induced a significantly greater expression of Fos-like immunoreactivity in striatum of rats treated three days previously with D-amphetamine compared to rats treated three days previously with saline. This increase in the expression of Fos-like immunoreactivity in rat striatum was characterized by a significantly greater number of immunoreactive nuclei and a significant increase in the intensity of the immunoreactivity. This sensitization of c-fos expression following a repeated administration of D-amphetamine indicates an increased activation of post-synaptic elements in rat striatum.
引用
收藏
页码：125 / 128
页数：4
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