BIOPSY SPECIMEN IDENTIFICATION BY DETECTION OF SEX-CHROMOSOMES - APPLICATION OF INSITU HYBRIDIZATION

被引：9
作者：
KIBBELAAR, RE
LEENHEERSBINNENDIJK, CF
SPAANDER, PJ
KLUIN, PM
机构：
[1] Laboratory of Pathology, State University Leiden, 2300 RC Leiden
来源：
JOURNAL OF CLINICAL PATHOLOGY | 1992年 / 45卷 / 02期
关键词：
D O I：
10.1136/jcp.45.2.149
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Aims: To investigate the feasibility of non-radioactive in situ hybridisation (ISH) for the identification of sex-mismatched plastic embedded bone marrow biopsy specimens. Methods: After a suspected accidental transposition of two glycolmethacrylate embedded bone marrow specimens, in situ hybridisation with sex chromosome specific probes was performed. Results: Quantitative analysis of the hybridisation signals established unequivocably the origin of the specimens. Conclusions: ISH is feasible on GMA embedded bone marrow specimens, and can be used for the identification of accidentally transposed specimens provided that they are of sex-matched origin.
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页码：149 / 150
页数：2
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