A STUDY OF ADJUNCTIVE COPPER-SULFATE TREATMENT IN PATIENTS WITH RHEUMATOID-ARTHRITIS WHO HAVE RELAPSED WHILE TAKING D-PENICILLAMINE

被引：1

作者：

PULLAR, T

WRIGLEY, H

NEWTON, K

TOOTHILL, C

WRIGHT, V

机构：

[1] UNIV LEEDS,GEN INFIRM,DEPT CHEM PATHOL,LEEDS LS1 3EX,W YORKSHIRE,ENGLAND

[2] UNIV LEEDS,GEN INFIRM,CLIN PHARMACOL UNIT,LEEDS LS1 3EX,W YORKSHIRE,ENGLAND

[3] ROYAL BATH HOSP,CLIN PHARMACOL UNIT,HARROGATE,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 31卷 / 01期

关键词：

D-PENICILLAMINE; COPPER SULFATE; RHEUMATOID ARTHRITIS;

D O I：

10.1111/j.1365-2125.1991.tb03866.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Formation of a D-penicillamine-copper complex may be necessary for the anti-rheumatic effect of D-penicillamine. Thus, depletion of copper stores by D-penicillamine may eventually lead to relapse in D-penicillamine treated patients. Twenty-one patients who relapsed on D-penicillamine were randomised to copper sulphate 20 mg daily (n = 13) or matched placebo (n = 8) in addition to penicillamine daily for 16 weeks. Urinary copper was increased in the copper treated patients but no statistically significant or clinically important improvement occurred in either group.

引用

页码：105 / 107

页数：3