Chemistry and Bifunctional Chelating Agents for Binding Lu-177

被引：16
作者：
Parus, Jozef L. [1 ]
Pawlak, Dariusz [1 ]
Mikolajczak, Renata [1 ]
Duatti, Adriano [2 ]
机构：
[1] Natl Ctr Nucl Res, Radioisotope Ctr POLATOM, PL-05400 Otwock, Poland
[2] Univ Ferrara, Nucl Med Lab, I-44121 Ferrara, Italy
来源：
CURRENT RADIOPHARMACEUTICALS | 2015年 / 8卷 / 02期
关键词：
Bifunctional chelators; chemistry of lutetium; DOTA; DTPA; lanthanides; Lutetium; lutetium-177; radiopharmaceuticals; NOTA;
D O I：
10.2174/1874471008666150312160440
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A short overview of fundamental chemistry of lutetium and of structural characteristics of lutetium coordination complexes, as relevant for understanding the properties of lutetium-177 radio-pharmaceuticals, is presented. This includes basic concepts on lutetium electronic structure, lanthanide contraction, coordination geometries, behavior in aqueous solution and thermodynamic stability. An illustration of the structure and binding properties of the most important chelating agents for the Lu3+ ion in aqueous solution is also reported with specific focus on coordination complexes formed with linear and macrocyclic polydentate amino-carboxylate donor ligands.
引用
收藏
页码：86 / 94
页数：9
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