Anti-Ro and anti-La autoantibodies induce TNF-alpha production by human salivary gland cells: an in vitro study

被引：7

作者：

Sisto, M. ^{[1
]}

Lisi, S. ^{[1
]}

D'Amore, M. ^{[2
]}

Mitolo, V. ^{[1
]}

Scagliusi, P. ^{[2
]}

机构：

[1] Univ Bari, Dipartimento Anat Umana & Istol, Bari, Italy

[2] Univ Bari, Sez Reumatol, Dipartimento Med Interna & Med Pubbl, Bari, Italy

来源：

REUMATISMO | 2007年 / 59卷 / 03期

关键词：

Tumor necrosis factor alpha; autoantibodies; Siogren's syndrome;

D O I：

10.4081/reumatismo.2007.221

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this report, we demonstrate that both TNFR1 and the TNFR2 are expressed on the salivary gland cell line A-253 cell membrane. Furthermore, cell treatment with anti- Ro and anti- La autoantibodies from Sjogren IgG determined TNF-a production, clarifying which could be the inducer of the extrinsic pathway of apoptosis in salivary gland cells.

引用

页码：221 / 226

页数：6

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