Safety and Efficacy of Acamprosate for the Treatment of Alcohol Dependence

被引：27
作者：
Yahn, Stephanie L. [1 ]
Watterson, Lucas R. [1 ]
Olive, M. Foster [1 ,2 ]
机构：
[1] Arizona State Univ, Dept Psychol, Program Behav Neurosci, Tempe, AZ 85287 USA
[2] Arizona State Univ, Interdisciplinary Grad Program Neurosci, Tempe, AZ 85287 USA
来源：
SUBSTANCE ABUSE-RESEARCH AND TREATMENT | 2013年 / 7卷
关键词：
acamprosate; alcoholism; dependence; craving; amino acid; glutamate; pharmacotherapy;
D O I：
10.4137/SART.S9345
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Acamprosate (calcium acetylhomotaurine) is an amino acid modulator that has displayed efficacy in some clinical trials in reducing craving and promoting abstinence in alcohol dependent patients following detoxification. While acamprosate is safe and generally well-tolerated, not all studies have demonstrated clinical efficacy that is superior to placebo. In addition, the precise neurochemical mechanisms of action of acamprosate have still not yet been identified. In this review, we summarize current clinical data on the safety, efficacy, and pharmacokinetic properties of acamprosate, as well theories on its potential mechanism of action. We also discuss tolerability and patient preference issues and conclude with a discussion of the place of acamprosate in addiction medicine and therapy.
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页码：1 / 12
页数：12
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