PASSIVE-IMMUNIZATION OF MICE AGAINST D-FACTOR BLOCKS LETHALITY AND CYTOKINE RELEASE DURING ENDOTOXEMIA

被引：39

作者：

BLOCK, MI ^{[1
]}

BERG, M ^{[1
]}

MCNAMARA, MJ ^{[1
]}

NORTON, JA ^{[1
]}

FRAKER, DL ^{[1
]}

ALEXANDER, HR ^{[1
]}

机构：

[1] NCI,SURG BRANCH,SURG METAB SECT,BLDG 10,ROOM 2B17,BETHESDA,MD 20892

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1993年 / 178卷 / 03期

关键词：

D O I：

10.1084/jem.178.3.1085

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

D factor, also known as leukemia inhibitory factor, is a pleiotropic cytokine whose role during acute injury and inflammation is not known. Intraperitoneal administration of Escherichia coli endotoxin induced D factor gene expression in mice, and passive immunization against D factor protected them from the lethal effects of endotoxin and blocked endotoxin-induced increases in serum levels of interleukin 1 and 6. Peak levels of tumor necrosis factor and interferon gamma were not affected. These results indicate that D factor is an essential early mediator of the inflammatory cytokine response and therefore may be important in the pathogenesis of the many inflammatory conditions, such as sepsis, arthritis, allograft rejection, and cancer immunotherapy.

引用

页码：1085 / 1090

页数：6

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