ADRENALECTOMY CAUSES A DELAYED INCREASE OF INACTIVE PLASMA-RENIN IN RATS

被引：2

作者：

NIELSEN, AH ^{[1
]}

JOHANNESSEN, A ^{[1
]}

POULSEN, K ^{[1
]}

机构：

[1] ROYAL VET & AGR UNIV,INST ANAT & PHYSIOL,13 BULOWSVEJ,DK-1870 FREDERIKSBERG C,DENMARK

来源：

JOURNAL OF HYPERTENSION | 1991年 / 9卷 / 03期

关键词：

ADRENALECTOMY; ANGIOTENSINOGEN; INACTIVE RENIN; RENIN;

D O I：

10.1097/00004872-199103000-00007

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Using a new assay for inactive renin in rat plasma, inactive renin was unchanged 24 h after bilateral adrenalectomy but increased about threefold, from 0.43 Goldblatt units (GU)/I (range 0.27-0.62 GU/I; n = 14) to 1.24 GU/I (0.74-1.94 GU/I; n = 14) after 48 h. The increase was abolished by substitution with the mineralocorticoid deoxycorticosterone acetate. The results are in accordance with the high plasma concentration of inactive renin, previously reported in humans with adrenal insufficiency, and do not support activation of inactive renin in the circulation.

引用

页码：239 / 240

页数：2

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