ACCURATE ASSESSMENT OF INTRAGENIC RECOMBINATION FREQUENCY WITHIN THE DUCHENNE MUSCULAR-DYSTROPHY GENE

被引：90

作者：

ABBS, S

ROBERTS, RG

MATHEW, CG

BENTLEY, DR

BOBROW, M

机构：

来源：

GENOMICS | 1990年 / 7卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0888-7543(90)90205-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Polymorphic loci that lie at the two extremities of the Duchenne/Becker muscular dystrophy ( DMD BMD) gene have been used to estimate intragenic recombination rates. Multipoint linkage analysis of the CEPH panel of families suggests a total intragenic recombination frequency of nearly 0.12 (confidence intervals 0.041-0.226) over the genomic length of approximately 2 Mb. © 1990.

引用

页码：602 / 606

页数：5

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