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SOMATIC RIBOSOMAL CHANGES INDUCED BY LONG-TERM POTENTIATION OF THE PERFORANT PATH HIPPOCAMPAL CA1 SYNAPSES
被引：13
|作者：
WENZEL, J
DESMOND, NL
LEVY, WB
机构：
[1] Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville
关键词：
HIPPOCAMPUS;
RIBOSOME;
ULTRASTRUCTURE;
SYNAPTIC PLASTICITY;
LONG-TERM POTENTIATION;
PROTEIN SYNTHESIS;
D O I：
10.1016/0006-8993(93)91629-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study quantified ribosomes, as an ultrastructural marker of neuronal protein synthesis, following long-term potentiation (LTP) in the hippocampal CA1 region in vitro. Sixty min after LTP-inducing, high-frequency stimulation of the perforant path, the total number of ribosomes, the number of polysomes, and the number of membrane-bound ribosomes increased significantly. These increases are a postsynaptic morphological correlate consistent with enhanced protein synthesis following the induction of LTP in the perforant path-CA1 system.
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页码：331 / 333
页数：3
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