EXPERIMENTAL RETINAL TOLERANCE TO EMULSIFIED SILICONE OIL

被引：38

作者：

OHIRA, A ^{[1
]}

WILSON, CA ^{[1
]}

DEJUAN, E ^{[1
]}

MURATA, Y ^{[1
]}

SOJI, T ^{[1
]}

OSHIMA, K ^{[1
]}

机构：

[1] DUKE UNIV,CTR EYE,BOX 3802,DURHAM,NC 27710

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 1991年 / 11卷 / 02期

关键词：

Animal; Emulsification; Retinal toxicity; Silicone oil;

D O I：

10.1097/00006982-199111020-00012

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Vitreous replacement by silicone oil has become increasingly popular in the treatment of severe and complicated retinal detachment. Several studies have suggested that silicone oil may be toxic to the retina or may stimulate periretinal proliferation. To better understand its effects, emulsified or nonemulsified silicone oil was injected into rabbit eyes that had undergone mechanical vitrectomy. Silicone oil was labeled with phthalocyanine blue to aid in histologic localization. Retinal changes were compared by light microscopy at 1, 4, and 12 weeks after intraocular injection. Emulsified silicone oil was found to penetrate the inner retina at 1 week and cause epiretinal membrane formation as early as 4 weeks after injection. Nonemulsified oil produced no histologic changes in the retina. No cytotoxic effects were observed in eyes treated with ether emulsified or nonemulsified silicone oil. It is concluded that emulsified silicone oil can both penetrate the retina and stimulate epiretinal membrane formation in the vitrectomized rabbit eye.

引用

页码：259 / 265

页数：7

共 30 条

[1]

Cibis P.A., Becker B., Okun E., Canaan S., The use of liquid silicone in retinal detachment surgery, Arch Ophthalmol, 68, pp. 590-599, (1962)

[2]

Federman J.L., Schubert H.D., Complications associated with the use of silicone oil in 150 eyes after retina-vitreous surgery, Ophthalmology, 95, pp. 870-876, (1988)

[3]

McCuen B.W., DeJuan E., Landers M.B., Machemer R., Silicone oil in vitreoretinal surgery, Retina, 5, pp. 198-205, (1985)

[4]

Zilis J.D., McCuen B.W., Dejuan E., Et al., Results of silicone oil removal in advanced proliferative vitreoretinopathy, Am J Ophthalmol, 108, pp. 15-21, (1989)

[5]

Cockerham W., Schepens C.L., Freeman H.M., Silicone injection in retinal detachment, Mod Probl Ophthalmol, 8, pp. 525-540, (1969)

[6]

Blodi F.C., Injection and impregnation of liquid silicone into ocular tissues, Am J Ophthalmol, 71, pp. 1044-1051, (1971)

[7]

Watzke R.C., Silicone retinopoiesis for retinal detachment, Arch Ophthalmol, 77, pp. 185-196, (1967)

[8]

Laroche L., Pavlakis C., Saraux H., Orcel L., Ocular findings following intravitreal silicone injection, Arch Ophthalmol, 101, pp. 1422-1425, (1983)

[9]

Ni C., Wang W.J., Albert D.M., Schepens C.L., Intravitreous silicone injection: Histopathologic findings in a human eye after 12 years, Arch Ophthalmol, 101, pp. 1399-1401, (1983)

[10]

Leaver P.K., Grey R.H.B., Garner A., Silicone oil injection in the treatment of massive preretinal retraction, Br J Ophthalmol, 63, pp. 361-367, (1979)

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